Why Some Patients Are Switching from Trulicity to Mounjaro or Zepbound

Why Some Patients Are Switching from Trulicity to Mounjaro or Zepbound

If you’ve been using Trulicity (dulaglutide) to manage type 2 diabetes or help with weight loss, you may be hearing more about Mounjaro and Zepbound—two newer medications making headlines. Trulicity has been a trusted GLP-1 receptor agonist for years, but some patients are now considering alternatives for stronger outcomes and better pricing options. This is especially true for Americans without insurance coverage or with high co-pays.

Through services like Over the Border Meds, U.S. patients can now access Mounjaro and Zepbound from Canada at a significantly lower cost than buying locally—making the switch even more appealing.

How Does Trulicity Compare to Mounjaro and Zepbound?

Trulicity, Mounjaro, and Zepbound all belong to the GLP-1 family, a group of medications that helps regulate blood sugar, reduce appetite, and promote weight loss. However, Mounjaro (tirzepatide) has a dual mechanism of action, targeting both GLP-1 and GIP receptors. This means it can provide greater benefits for some patients, especially in A1C reduction and weight loss.

According to studies:

  • Trulicity may lower A1C by ~1.0–1.5%

  • Mounjaro can reduce A1C by up to 2.4%

  • Zepbound (the weight-loss version of Mounjaro) shows even greater weight reduction effects

For many patients, this makes Mounjaro and Zepbound worth considering—especially when results have plateaued on Trulicity.

All six doses of Zepbound pens

Zepbound now Available from Canada!

Buy Now

What Is Zepbound and How Is It Different?

Zepbound is essentially Mounjaro rebranded and FDA-approved for weight loss, not diabetes. It contains the same active ingredient, tirzepatide, and works the same way. The only real difference is in the indication: Zepbound is prescribed specifically for obesity or overweight individuals with weight-related conditions like high blood pressure or high cholesterol.

This means that even if you were using Trulicity for weight loss alone, Zepbound may be a more appropriate choice going forward.

And good news—Zepbound is now officially available in Canada, and Over the Border Meds can help U.S. patients access it affordably.

All strengths of Mounjaro Kwikpens

Cost Savings: Buying Mounjaro and Zepbound from Canada

One of the biggest reasons patients are making the switch from Trulicity is cost. In the United States:

  • Trulicity can cost upwards of $950/month

  • Mounjaro is around $1,100/month

  • Zepbound is also $1,000+ without insurance

However, through Canadian prescription referral services like Over the Border Meds, you can get:

  • Mounjaro for as low as $569/month

  • Zepbound starting from $599/month

  • Trulicity is also available at lower costs than U.S. retail pharmacies

For those micro-dosing or counting clicks to stretch their pens, the cost-per-dose becomes even more affordable.

We Help You Transition Smoothly

Switching from Trulicity to Mounjaro or Zepbound isn’t difficult, but it helps to have support. Our pharmacy partners and pharmacists can:

  • Review equivalent dosing

  • Help you understand how to count clicks if micro-dosing

  • Assist with transitioning from weekly injections of Trulicity to Mounjaro pens

  • Provide needle tips and titration guidance

Whether you’re switching for weight loss, better blood sugar control, or cost savings, we’re here to help.

Final Thoughts: Trulicity Still Works, But Better Options May Be Available

Trulicity remains a solid option for many patients, especially those who tolerate it well. But if your results have plateaued or you’re simply looking for a more cost-effective solution, Mounjaro and Zepbound may be better fits—both medically and financially.

Thanks to prescription referral services like Over the Border Meds, Americans can access these newer treatments without the high U.S. price tag. With vials, pens, and upcoming 15 mg KwikPen formats available, there’s never been a better time to explore your options.